Assay Detail
Binding
CHEMBL755486
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Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the cDNAs for rat Opioid receptor kappa 1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.85 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354545 | — | — | 1 | 9.09 |
| CHEMBL354291 | — | — | 1 | 8.68 |
| CHEMBL354652 | — | — | 1 | 8.54 |
| CHEMBL440928 | — | — | 1 | 8.41 |
| CHEMBL353990 | — | — | 1 | 8.04 |
| CHEMBL165885 | — | — | 1 | 7.92 |
| CHEMBL355202 | — | — | 1 | 7.70 |
| CHEMBL166387 | — | — | 1 | 7.58 |
| CHEMBL354065 | — | — | 1 | 7.54 |
| CHEMBL168578 | — | — | 1 | 7.51 |
| CHEMBL436243 | — | — | 1 | 7.42 |
| CHEMBL169947 | — | — | 1 | 7.24 |
| CHEMBL166445 | — | — | 1 | 7.24 |
| CHEMBL263575 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354545 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL354291 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL354652 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL440928 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL353990 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL165885 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL355202 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL166387 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL354065 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL168578 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL436243 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL169947 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL166445 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL263575 | — | Ki | = | 100.0 | nM | 7.00 |