Assay Detail
Binding
CHEMBL754684
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Binding affinity for micro receptors by the inhibition of binding of [3H]DAMGO to Opioid receptor mu 1 in human cloned receptors.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.21 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102150 | — | — | 1 | 5.48 |
| CHEMBL430675 | — | — | 1 | 5.35 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.32 |
| CHEMBL98691 | — | — | 1 | 5.22 |
| CHEMBL101316 | — | — | 1 | 5.22 |
| CHEMBL101231 | — | — | 1 | 5.21 |
| CHEMBL98800 | — | — | 1 | 5.17 |
| CHEMBL316845 | — | — | 1 | 5.01 |
| CHEMBL431276 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102150 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL430675 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL13470 | SNC-80 | IC50 | = | 4785.0 | nM | 5.32 |
| CHEMBL98691 | — | IC50 | = | 5999.0 | nM | 5.22 |
| CHEMBL101316 | — | IC50 | = | 6083.0 | nM | 5.22 |
| CHEMBL101231 | — | IC50 | = | 6186.0 | nM | 5.21 |
| CHEMBL98800 | — | IC50 | = | 6837.0 | nM | 5.17 |
| CHEMBL316845 | — | IC50 | = | 9724.0 | nM | 5.01 |
| CHEMBL431276 | — | IC50 | = | 12110.0 | nM | 4.92 |