Assay Detail
Functional
CHEMBL754741
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Inhibition of P388 Leukemia cell proliferation
13
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.43 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350558 | — | — | 1 | 6.22 |
| CHEMBL3350560 | — | — | 1 | 6.16 |
| CHEMBL326711 | — | — | 4 | 5.22 |
| CHEMBL117114 | — | — | 2 | 5.21 |
| CHEMBL3350557 | — | — | 1 | 5.17 |
| CHEMBL332728 | — | — | 4 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350558 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3350560 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL326711 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326711 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326711 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326711 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL117114 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL117114 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3350557 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL332728 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL332728 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL332728 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL332728 | — | IC50 | > | 15000.0 | nM | - |