Assay Detail
Functional
CHEMBL754744
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Effective concentration required to inhibit P388D1 cell death by 50%
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.26 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105995 | — | — | 1 | 6.90 |
| CHEMBL418813 | — | — | 1 | 6.87 |
| CHEMBL108431 | — | — | 1 | 6.84 |
| CHEMBL107284 | — | — | 1 | 6.82 |
| CHEMBL543394 | — | — | 1 | 6.75 |
| CHEMBL107659 | — | — | 1 | 6.62 |
| CHEMBL542927 | — | — | 1 | 5.96 |
| CHEMBL542692 | — | — | 1 | 5.94 |
| CHEMBL545507 | — | — | 1 | 5.90 |
| CHEMBL543157 | — | — | 1 | 5.68 |
| CHEMBL541576 | — | — | 1 | 5.58 |
| CHEMBL106298 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105995 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL418813 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL108431 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL107284 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL543394 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL107659 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL542927 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL542692 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL545507 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL543157 | — | EC50 | = | 2075.0 | nM | 5.68 |
| CHEMBL541576 | — | EC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL106298 | — | EC50 | = | 5800.0 | nM | 5.24 |