Assay Detail
Binding
CHEMBL754820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]- DPDPE from delta opioid receptor in rat brain membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of deltorphin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.06 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281140 | — | — | 1 | 8.96 |
| CHEMBL45308 | — | — | 1 | 8.62 |
| CHEMBL29078 | — | — | 1 | 8.44 |
| CHEMBL296749 | — | — | 1 | 8.23 |
| CHEMBL32202 | — | — | 1 | 8.21 |
| CHEMBL297059 | — | — | 1 | 8.13 |
| CHEMBL46540 | — | — | 1 | 7.96 |
| CHEMBL47156 | — | — | 1 | 7.80 |
| CHEMBL297567 | — | — | 1 | 7.75 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281140 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL45308 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL29078 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL296749 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL32202 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL297059 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL46540 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL47156 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL297567 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 320.0 | nM | 6.50 |