Assay Detail
Binding
CHEMBL754882
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In vitro binding affinity against Opioid receptor delta 1 (DPDPE) in rat brain homogenates.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.35 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 7.90 |
| CHEMBL610028 | — | — | 1 | 7.67 |
| CHEMBL610286 | — | — | 1 | 7.61 |
| CHEMBL610287 | — | — | 1 | 7.25 |
| CHEMBL610544 | — | — | 1 | 7.18 |
| CHEMBL610546 | — | — | 1 | 7.08 |
| CHEMBL610030 | — | — | 1 | 7.05 |
| CHEMBL610543 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL610028 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL610286 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL610287 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL610544 | — | Ki | = | 65.4 | nM | 7.18 |
| CHEMBL610546 | — | Ki | = | 82.6 | nM | 7.08 |
| CHEMBL610030 | — | Ki | = | 89.5 | nM | 7.05 |
| CHEMBL610543 | — | Ki | = | 96.4 | nM | 7.02 |