Assay Detail
Binding
CHEMBL754883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at opioid receptor delta 1 was determined in C6 rat glioma cells using [3H]Ile5,6 deltorphin II
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C6 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.68 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606986 | — | — | 1 | 10.05 |
| CHEMBL606925 | — | — | 1 | 9.59 |
| CHEMBL606924 | — | — | 1 | 9.34 |
| CHEMBL514774 | — | — | 1 | 9.32 |
| CHEMBL606985 | — | — | 1 | 9.03 |
| CHEMBL606987 | — | — | 1 | 8.90 |
| CHEMBL606923 | — | — | 1 | 8.27 |
| CHEMBL606876 | — | — | 1 | 8.21 |
| CHEMBL326684 | — | — | 1 | 7.39 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606986 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL606925 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL606924 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL514774 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL606985 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL606987 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL606923 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL606876 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL326684 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL70 | MORPHINE | Ki | = | 217.0 | nM | 6.66 |