Assay Detail
Functional
CHEMBL754895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cell growth inhibitory activity against amsacrine-resistant P388 cell line (P388/A)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.90 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37656 | — | — | 1 | 6.14 |
| CHEMBL9940 | — | — | 1 | 5.70 |
| CHEMBL1203817 | — | — | 1 | 5.70 |
| CHEMBL1203823 | — | — | 1 | 5.36 |
| CHEMBL1203822 | — | — | 1 | 5.34 |
| CHEMBL1203808 | — | — | 1 | 5.16 |
| CHEMBL1203814 | — | — | 1 | 5.11 |
| CHEMBL2448055 | — | — | 1 | 5.11 |
| CHEMBL1203834 | — | — | 1 | 5.10 |
| CHEMBL2448056 | — | — | 1 | 5.10 |
| CHEMBL1203815 | — | — | 1 | 4.90 |
| CHEMBL1203807 | — | — | 1 | 4.90 |
| CHEMBL1203809 | — | — | 1 | 4.90 |
| CHEMBL1203827 | — | — | 1 | 4.84 |
| CHEMBL1203830 | — | — | 1 | 4.80 |
| CHEMBL1203820 | — | — | 1 | 4.65 |
| CHEMBL2448054 | — | — | 1 | 4.65 |
| CHEMBL1203811 | — | — | 1 | 4.63 |
| CHEMBL1203826 | — | — | 1 | 4.61 |
| CHEMBL1203813 | — | — | 1 | 4.61 |
| CHEMBL1203818 | — | — | 1 | 4.59 |
| CHEMBL1203819 | — | — | 1 | 4.53 |
| CHEMBL1203810 | — | — | 1 | 4.52 |
| CHEMBL1203824 | — | — | 1 | 4.49 |
| CHEMBL1203812 | — | — | 1 | 4.47 |
| CHEMBL1203825 | — | — | 1 | 4.45 |
| CHEMBL165595 | — | — | 1 | 4.44 |
| CHEMBL1203835 | — | — | 1 | 4.40 |
| CHEMBL1203829 | — | — | 1 | - |
| CHEMBL1203821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37656 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL9940 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1203817 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1203823 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1203822 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1203808 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1203814 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL2448055 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1203834 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2448056 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1203815 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1203807 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1203809 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1203827 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1203830 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL1203820 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL2448054 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1203811 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL1203826 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL1203813 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL1203818 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL1203819 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL1203810 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL1203824 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1203812 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL1203825 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL165595 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL1203835 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1203829 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1203821 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1203828 | — | IC50 | > | 40000.0 | nM | - |