Assay Detail
Functional
CHEMBL754900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against P388 mouse leukemia cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.72 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.82 |
| CHEMBL7877 | — | — | 1 | 6.68 |
| CHEMBL440642 | — | — | 1 | 6.60 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.52 |
| CHEMBL269139 | — | — | 1 | 6.44 |
| CHEMBL267251 | — | — | 1 | 6.41 |
| CHEMBL428339 | — | — | 1 | 6.33 |
| CHEMBL268458 | — | — | 1 | 6.17 |
| CHEMBL7690 | — | — | 1 | 6.06 |
| CHEMBL7368 | — | — | 1 | 6.03 |
| CHEMBL8063 | — | — | 1 | 5.96 |
| CHEMBL7534 | — | — | 1 | 5.82 |
| CHEMBL7769 | — | — | 1 | 5.68 |
| CHEMBL7960 | — | — | 1 | 5.66 |
| CHEMBL8161 | — | — | 1 | 5.14 |
| CHEMBL414022 | — | — | 1 | 4.82 |
| CHEMBL7972 | — | — | 1 | 4.70 |
| CHEMBL7848 | — | — | 1 | 4.70 |
| CHEMBL266463 | — | — | 1 | 4.68 |
| CHEMBL8179 | WIN-57294 | — | 1 | 4.54 |
| CHEMBL7831 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL7877 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL440642 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL269139 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL267251 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL428339 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL268458 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL7690 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL7368 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL8063 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL7534 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL7769 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7960 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL8161 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL414022 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL7972 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7848 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL266463 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL8179 | WIN-57294 | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL7831 | — | IC50 | = | 37000.0 | nM | 4.43 |