Assay Detail
Functional
CHEMBL754903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against doxorubicin resistant P388 cell lines
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 3-alkyl- and 3-alkenyl-3-dephenyldocetaxels
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.49 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89290 | — | — | 1 | 5.80 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 5.73 |
| CHEMBL89748 | — | — | 1 | 5.63 |
| CHEMBL89296 | — | — | 1 | 5.16 |
| CHEMBL316368 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89290 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL89748 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL89296 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL316368 | — | IC50 | = | 7490.0 | nM | 5.13 |