Assay Detail
Binding
CHEMBL754935
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Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.77 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372328 | — | — | 1 | 9.29 |
| CHEMBL2372327 | — | — | 1 | 9.15 |
| CHEMBL2372314 | — | — | 1 | 9.00 |
| CHEMBL2372310 | — | — | 1 | 8.92 |
| CHEMBL339320 | — | — | 1 | 8.85 |
| CHEMBL31421 | — | — | 1 | 8.24 |
| CHEMBL2372329 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372328 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL2372327 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL2372314 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2372310 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL339320 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL31421 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2372329 | — | IC50 | = | 12.0 | nM | 7.92 |