Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL754936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL269)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ.
J Med Chem (1998) 41 : 4767 -4776
PubMed 9822547 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.56 9.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25230 1 9.51
CHEMBL13470 SNC-80 1 8.97
CHEMBL31421 1 8.80
CHEMBL143939 1 8.80
CHEMBL143592 3 8.39
CHEMBL150625 1 8.30
CHEMBL356778 1 7.51
CHEMBL356587 1 7.47
CHEMBL407250 1 6.64
CHEMBL145093 1 6.38
CHEMBL142681 1 6.21
CHEMBL145371 1 5.75
CHEMBL145131 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25230 IC50 = 0.31 nM 9.51
CHEMBL13470 SNC-80 IC50 = 1.06 nM 8.97
CHEMBL31421 IC50 = 1.6 nM 8.80
CHEMBL143939 IC50 = 1.6 nM 8.80
CHEMBL143592 IC50 = 4.1 nM 8.39
CHEMBL150625 IC50 = 5.0 nM 8.30
CHEMBL143592 IC50 = 8.4 nM 8.08
CHEMBL356778 IC50 = 31.0 nM 7.51
CHEMBL356587 IC50 = 34.0 nM 7.47
CHEMBL143592 IC50 = 42.0 nM 7.38
CHEMBL407250 IC50 = 230.0 nM 6.64
CHEMBL145093 IC50 = 420.0 nM 6.38
CHEMBL142681 IC50 = 610.0 nM 6.21
CHEMBL145371 IC50 = 1800.0 nM 5.75
CHEMBL145131 IC50 = 6400.0 nM 5.19