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Assay Detail

CHEMBL755047

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Functional
Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

P2Y purinoceptor 11 (CHEMBL4867)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Purine and pyrimidine (P2) receptors as drug targets.
Jacobson KA, Jarvis MF, Williams M.
J Med Chem (2002) 45 : 4057 -4093
PubMed 12213051 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 5.02 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL336292 1 5.82
CHEMBL131890 ATPGAMMAS 1 5.52
CHEMBL339386 1 5.16
CHEMBL335538 1 5.05
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 4.77
CHEMBL335206 1 4.52
CHEMBL336208 1 4.30
CHEMBL336296 URIDINE TRIPHOSPHATE 3.0 1 -
CHEMBL3085531 1 -
CHEMBL223344 RB 2 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL336292 EC50 = 1500.0 nM 5.82
CHEMBL131890 ATPGAMMAS EC50 = 3000.0 nM 5.52
CHEMBL339386 EC50 = 7000.0 nM 5.16
CHEMBL335538 EC50 = 9000.0 nM 5.05
CHEMBL14249 ADENOSINE TRIPHOSPHATE EC50 = 17000.0 nM 4.77
CHEMBL335206 EC50 = 30000.0 nM 4.52
CHEMBL336208 EC50 = 50000.0 nM 4.30
CHEMBL336296 URIDINE TRIPHOSPHATE EC50 > 100000.0 nM -
CHEMBL3085531 EC50 > 100000.0 nM -
CHEMBL223344 RB 2 EC50 > 100000.0 nM -