Assay Detail
Binding
CHEMBL755070
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Binding ability towards opioid receptor delta expressed in homogenates of rat brain.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.34 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311145 | — | — | 1 | 8.40 |
| CHEMBL74791 | — | — | 1 | 7.92 |
| CHEMBL309491 | — | — | 1 | 7.68 |
| CHEMBL76527 | — | — | 1 | 7.34 |
| CHEMBL307595 | — | — | 1 | 6.96 |
| CHEMBL76816 | — | — | 1 | 6.63 |
| CHEMBL420562 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311145 | — | IC50 | = | 3.98 | nM | 8.40 |
| CHEMBL74791 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL309491 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL76527 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL307595 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL76816 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL420562 | — | IC50 | = | 340.0 | nM | 6.47 |