Assay Detail
Binding
CHEMBL755078
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Binding affinity against Nicotinic acetylcholine receptor using [3H](-)-nicotine radioligand
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal nicotinic acetylcholine receptor (CHEMBL3350222) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Mus musculus |
Publication
(-)6-n-Propylnicotine antagonizes the antinociceptive effects of (-)nicotine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.11 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 2 | 8.92 |
| CHEMBL294757 | — | — | 1 | 8.74 |
| CHEMBL103225 | — | — | 1 | 8.25 |
| CHEMBL320023 | — | — | 1 | 7.68 |
| CHEMBL103537 | — | — | 2 | 7.66 |
| CHEMBL103566 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3 | NICOTINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL294757 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL103225 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL320023 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL103537 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL103537 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL103566 | — | Ki | = | 72.0 | nM | 7.14 |