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Compound Detail

CHEMBL103537

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CCCc1ccc(C2CCCN2C)cn1

Basic Information

ChEMBL ID CHEMBL103537
Phase Preclinical
Structure Type MOL
InChI Key PRZWMEZZLSVZHL-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

204.3
MW (Da)
2.80
ALogP
2
HBA
0
HBD
16.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H20N2
MW 204.32
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -0.23

Activity Summary

Ki 3 meas. best 7.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor; alpha4/beta2
CHEMBL1907596
Ki 7.77 7.77 17.0 1
Neuronal nicotinic acetylcholine receptor
CHEMBL3350222
Ki 7.66 7.63 22.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12270194 10.1016/s0960-894x(02)00614-5 Mus musculus 4
12270194 10.1016/s0960-894x(02)00614-5 Neuronal nicotinic acetylcholine receptor 2
12270194 10.1016/s0960-894x(02)00614-5 Rattus norvegicus 2
15925512 10.1016/j.bmcl.2005.04.072 Neuronal acetylcholine receptor; alpha4/beta2 1

Data from ChEMBL 36 via Core Engine