Assay Detail
Binding
CHEMBL755204
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Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.08 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790572 | — | — | 1 | 5.70 |
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 5.70 |
| CHEMBL384284 | — | — | 1 | 5.55 |
| CHEMBL413950 | — | — | 1 | 5.35 |
| CHEMBL414987 | — | — | 1 | 5.25 |
| CHEMBL437283 | — | — | 1 | 5.08 |
| CHEMBL507214 | — | — | 1 | 4.87 |
| CHEMBL274298 | — | — | 1 | 4.56 |
| CHEMBL440061 | — | — | 1 | 4.50 |
| CHEMBL263342 | — | — | 1 | 4.24 |
| CHEMBL274400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790572 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1823872 | SOMATOSTATIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL384284 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL413950 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL414987 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL437283 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL507214 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL274298 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL440061 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL263342 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL274400 | — | IC50 | > | 70000.0 | nM | - |