Assay Detail
Binding
CHEMBL755210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]deltorphin binding to Opioid receptor delta 1 using rat brain membranes.
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.03 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150625 | — | — | 1 | 8.30 |
| CHEMBL143592 | — | — | 1 | 8.08 |
| CHEMBL151416 | — | — | 1 | 7.96 |
| CHEMBL151341 | — | — | 1 | 7.48 |
| CHEMBL149795 | — | — | 1 | 7.42 |
| CHEMBL357746 | — | — | 1 | 7.42 |
| CHEMBL357975 | — | — | 1 | 4.90 |
| CHEMBL424324 | — | — | 2 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150625 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL143592 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL151416 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL151341 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL149795 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL357746 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL357975 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL424324 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL424324 | — | IC50 | > | 10000.0 | nM | - |