Assay Detail
Binding
CHEMBL755211
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Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1.
32
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.18 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 8.77 |
| CHEMBL290301 | — | — | 3 | 8.25 |
| CHEMBL288803 | — | — | 3 | 8.24 |
| CHEMBL288495 | — | — | 1 | 8.16 |
| CHEMBL70 | MORPHINE | 4.0 | 2 | 8.13 |
| CHEMBL289157 | — | — | 1 | 7.90 |
| CHEMBL288729 | — | — | 1 | 7.75 |
| CHEMBL39994 | — | — | 1 | 7.47 |
| CHEMBL288730 | — | — | 1 | 7.39 |
| CHEMBL39531 | — | — | 1 | 7.33 |
| CHEMBL290557 | — | — | 1 | 7.16 |
| CHEMBL38086 | — | — | 1 | 7.08 |
| CHEMBL37584 | — | — | 1 | 6.95 |
| CHEMBL436351 | — | — | 1 | 6.85 |
| CHEMBL38961 | — | — | 1 | 6.74 |
| CHEMBL290095 | — | — | 1 | 6.64 |
| CHEMBL430732 | — | — | 1 | 6.64 |
| CHEMBL288669 | — | — | 1 | 6.63 |
| CHEMBL38791 | — | — | 3 | 6.56 |
| CHEMBL39886 | — | — | 1 | 6.31 |
| CHEMBL40188 | — | — | 1 | 5.98 |
| CHEMBL434203 | — | — | 1 | - |
| CHEMBL39319 | — | — | 1 | - |
| CHEMBL285250 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL290301 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL288803 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL288803 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL288495 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL290301 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL70 | MORPHINE | IC50 | = | 7.37 | nM | 8.13 |
| CHEMBL289157 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL288729 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL39994 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL288730 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL39531 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL290557 | — | IC50 | = | 69.5 | nM | 7.16 |
| CHEMBL38086 | — | IC50 | = | 84.1 | nM | 7.08 |
| CHEMBL37584 | — | IC50 | = | 111.3 | nM | 6.95 |
| CHEMBL436351 | — | IC50 | = | 140.1 | nM | 6.85 |
| CHEMBL38961 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL430732 | — | IC50 | = | 227.1 | nM | 6.64 |
| CHEMBL290095 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL288669 | — | IC50 | = | 233.3 | nM | 6.63 |
| CHEMBL38791 | — | IC50 | = | 273.4 | nM | 6.56 |
| CHEMBL39886 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL290301 | — | IC50 | = | 660.1 | nM | 6.18 |
| CHEMBL70 | MORPHINE | IC50 | = | 684.0 | nM | 6.17 |
| CHEMBL38791 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL40188 | — | IC50 | = | 1052.0 | nM | 5.98 |
| CHEMBL38791 | — | IC50 | = | 1136.0 | nM | 5.95 |
| CHEMBL285250 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL39319 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL434203 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL285250 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL288803 | — | IC50 | > | 1000.0 | nM | - |