Assay Detail
Binding
CHEMBL755215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration was evaluated against delta opioid receptor by the displacement of tritiated DSLET from rat brain membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.05 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110229 | — | — | 1 | 8.10 |
| CHEMBL171763 | — | — | 1 | 8.02 |
| CHEMBL353943 | — | — | 1 | 8.00 |
| CHEMBL169183 | — | — | 1 | 6.91 |
| CHEMBL2110337 | — | — | 1 | 6.88 |
| CHEMBL2110227 | — | — | 1 | 5.75 |
| CHEMBL170594 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110229 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL171763 | — | IC50 | = | 9.57 | nM | 8.02 |
| CHEMBL353943 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL169183 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2110337 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL2110227 | — | IC50 | = | 1799.0 | nM | 5.75 |
| CHEMBL170594 | — | IC50 | = | 2094.0 | nM | 5.68 |