Assay Detail
Functional
CHEMBL755232
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Cytotoxicity against P388/CPT5 leukemia cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.43 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345881 | — | — | 1 | 6.03 |
| CHEMBL347195 | — | — | 1 | 5.50 |
| CHEMBL347466 | — | — | 1 | 5.48 |
| CHEMBL345384 | — | — | 1 | 5.46 |
| CHEMBL156776 | — | — | 1 | 5.37 |
| CHEMBL156818 | — | — | 1 | 5.34 |
| CHEMBL347684 | — | — | 1 | 5.30 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 4.98 |
| CHEMBL154620 | — | — | 1 | - |
| CHEMBL3350557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345881 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL347195 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL347466 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL345384 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL156776 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL156818 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL347684 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL154620 | — | IC50 | > | 14400.0 | nM | - |
| CHEMBL3350557 | — | IC50 | > | 20000.0 | nM | - |