Assay Detail
Functional
CHEMBL755667
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Inhibition of proliferation of murine P388 cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxic activities of Mannich bases of chalcones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.15 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 6.66 |
| CHEMBL440640 | — | — | 1 | 6.25 |
| CHEMBL7803 | — | — | 1 | 6.06 |
| CHEMBL8015 | — | — | 1 | 5.60 |
| CHEMBL7709 | — | — | 1 | 5.55 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | 5.51 |
| CHEMBL8014 | — | — | 1 | 5.50 |
| CHEMBL7531 | — | — | 1 | 5.43 |
| CHEMBL538847 | — | — | 1 | 5.43 |
| CHEMBL7809 | — | — | 1 | 5.42 |
| CHEMBL8067 | — | — | 1 | 5.33 |
| CHEMBL555363 | — | — | 1 | 5.29 |
| CHEMBL7973 | — | — | 1 | 5.26 |
| CHEMBL545128 | — | — | 1 | 5.26 |
| CHEMBL545358 | — | — | 1 | 5.26 |
| CHEMBL557588 | — | — | 1 | 5.23 |
| CHEMBL269163 | — | — | 1 | 5.16 |
| CHEMBL274303 | — | — | 1 | 5.10 |
| CHEMBL274170 | — | — | 1 | 5.07 |
| CHEMBL8102 | — | — | 1 | 5.07 |
| CHEMBL557383 | — | — | 1 | 5.06 |
| CHEMBL268559 | — | — | 1 | 5.06 |
| CHEMBL536104 | — | — | 1 | 5.05 |
| CHEMBL7575 | — | — | 1 | 5.05 |
| CHEMBL7976 | CHALCONE | — | 1 | 5.02 |
| CHEMBL542045 | — | — | 1 | 4.99 |
| CHEMBL266293 | — | — | 1 | 4.99 |
| CHEMBL545127 | — | — | 1 | 4.96 |
| CHEMBL7721 | — | — | 1 | 4.93 |
| CHEMBL7668 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL440640 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL7803 | — | IC50 | = | 864.0 | nM | 6.06 |
| CHEMBL8015 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL7709 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL8014 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL7531 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL538847 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL7809 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL8067 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL555363 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL7973 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL545128 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL545358 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL557588 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL269163 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL274303 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL274170 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL8102 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL268559 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL557383 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL536104 | — | IC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL7575 | — | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL7976 | CHALCONE | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL542045 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL266293 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL545127 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL7721 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL7668 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL542780 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL266780 | — | IC50 | = | 13140.0 | nM | 4.88 |
| CHEMBL545593 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL536784 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL7457 | — | IC50 | = | 16650.0 | nM | 4.78 |
| CHEMBL555176 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL544894 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL537255 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL545130 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL537011 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL558976 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL545595 | — | IC50 | > | 50000.0 | nM | - |