Assay Detail
Functional
CHEMBL755735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound was tested against P388:Methotrexate resistant cells tumor growth cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.23 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41056 | — | — | 1 | 7.72 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 7.36 |
| CHEMBL42159 | — | — | 1 | 7.19 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.65 |
| CHEMBL42301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41056 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL42159 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL42301 | — | IC50 | > | 1.0 | nM | - |