Assay Detail
Functional
CHEMBL756348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against murine P388 leukemia cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.12 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.50 |
| CHEMBL51826 | — | — | 1 | 6.58 |
| CHEMBL3350558 | — | — | 1 | 6.22 |
| CHEMBL3350560 | — | — | 1 | 6.17 |
| CHEMBL3350557 | — | — | 1 | 6.16 |
| CHEMBL3350564 | — | — | 1 | 6.04 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 5.91 |
| CHEMBL52964 | — | — | 1 | 5.31 |
| CHEMBL3350565 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL51826 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3350558 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3350560 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3350557 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3350564 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL52964 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3350565 | — | IC50 | = | 6360.0 | nM | 5.20 |