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Assay Detail

CHEMBL756350

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Functional
Inhibitory activity against P388 murine leukemia cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Expert

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Bu X, Deady LW, Finlay GJ, Baguley BC, Denny WA.
J Med Chem (2001) 44 : 2004 -2014
PubMed 11384245 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.26 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65 CAMPTOTHECIN -1.0 1 7.89
CHEMBL43 AMSACRINE 4.0 1 7.70
CHEMBL276261 1 7.00
CHEMBL60129 1 6.96
CHEMBL64378 1 6.89
CHEMBL59664 1 6.47
CHEMBL64071 1 6.22
CHEMBL60794 1 6.10
CHEMBL303559 1 6.10
CHEMBL292079 1 6.05
CHEMBL61526 1 6.00
CHEMBL62324 1 5.89
CHEMBL294064 1 5.82
CHEMBL61064 1 5.64
CHEMBL433253 1 5.24
CHEMBL293209 1 5.21
CHEMBL292038 1 5.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65 CAMPTOTHECIN IC50 = 13.0 nM 7.89
CHEMBL43 AMSACRINE IC50 = 20.0 nM 7.70
CHEMBL276261 IC50 = 100.0 nM 7.00
CHEMBL60129 IC50 = 110.0 nM 6.96
CHEMBL64378 IC50 = 130.0 nM 6.89
CHEMBL59664 IC50 = 340.0 nM 6.47
CHEMBL64071 IC50 = 600.0 nM 6.22
CHEMBL60794 IC50 = 800.0 nM 6.10
CHEMBL303559 IC50 = 790.0 nM 6.10
CHEMBL292079 IC50 = 890.0 nM 6.05
CHEMBL61526 IC50 = 1000.0 nM 6.00
CHEMBL62324 IC50 = 1300.0 nM 5.89
CHEMBL294064 IC50 = 1500.0 nM 5.82
CHEMBL61064 IC50 = 2300.0 nM 5.64
CHEMBL433253 IC50 = 5800.0 nM 5.24
CHEMBL293209 IC50 = 6200.0 nM 5.21
CHEMBL292038 IC50 = 6600.0 nM 5.18