Assay Detail

CHEMBL756352

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Functional

Inhibitory activity against P388 Leukemia cells

ChEMBL ↗

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Target

P388 (CHEMBL389) ↗

Open DB target context

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P388 (CHEMBL389) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target P388

CHEMBL389

Anchored from Assay target.

Protein identity P388

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	P388
Confidence	1 — Organism
Curated By	Intermediate

Target

P388 (CHEMBL389) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Selective phenolic acylation of 10-hydroxycamptothecin using poly (ethylene glycol) carboxylic acid.

Greenwald RB, Choe YH, Wu D.
Bioorg Med Chem Lett (2003) 13 : 577 -580
PubMed 12565975 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.04	8.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL65	CAMPTOTHECIN	-1.0	1	8.15
CHEMBL273862	HYDROXYCAMPTOTHECIN	3.0	1	7.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL65	CAMPTOTHECIN	IC50	=	7.0	nM	8.15
CHEMBL273862	HYDROXYCAMPTOTHECIN	IC50	=	12.0	nM	7.92