Assay Detail
Binding
CHEMBL756354
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Binding affinity for mu opioid receptor
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New scaffolds in the development of mu opioid-receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 7.50 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 9.28 |
| CHEMBL39272 | — | — | 1 | 8.96 |
| CHEMBL288468 | — | — | 1 | 8.57 |
| CHEMBL41736 | — | — | 1 | 8.28 |
| CHEMBL40548 | — | — | 1 | 8.22 |
| CHEMBL41946 | — | — | 1 | 8.17 |
| CHEMBL40993 | — | — | 1 | 8.06 |
| CHEMBL290919 | — | — | 1 | 7.99 |
| CHEMBL40409 | — | — | 1 | 7.93 |
| CHEMBL38495 | — | — | 1 | 7.83 |
| CHEMBL285769 | — | — | 1 | 7.75 |
| CHEMBL287989 | — | — | 1 | 7.67 |
| CHEMBL41649 | — | — | 1 | 7.64 |
| CHEMBL40581 | — | — | 1 | 7.64 |
| CHEMBL40825 | — | — | 1 | 7.63 |
| CHEMBL40528 | — | — | 1 | 7.62 |
| CHEMBL41205 | — | — | 1 | 7.58 |
| CHEMBL43682 | — | — | 1 | 7.51 |
| CHEMBL288205 | — | — | 1 | 7.51 |
| CHEMBL289512 | — | — | 1 | 7.47 |
| CHEMBL418241 | — | — | 1 | 7.46 |
| CHEMBL39968 | — | — | 1 | 7.42 |
| CHEMBL40108 | — | — | 1 | 7.39 |
| CHEMBL290240 | — | — | 1 | 7.30 |
| CHEMBL290463 | — | — | 1 | 7.25 |
| CHEMBL416431 | — | — | 1 | 7.20 |
| CHEMBL41245 | — | — | 2 | 7.07 |
| CHEMBL287981 | — | — | 1 | 6.86 |
| CHEMBL418616 | — | — | 1 | 6.76 |
| CHEMBL41883 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL39272 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL288468 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL41736 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL40548 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL41946 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL40993 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL290919 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL40409 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL38495 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL285769 | — | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL287989 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL40581 | — | Ki | = | 22.7 | nM | 7.64 |
| CHEMBL41649 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL40825 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL40528 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL41205 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL43682 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL288205 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL289512 | — | Ki | = | 33.7 | nM | 7.47 |
| CHEMBL418241 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL39968 | — | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL40108 | — | Ki | = | 40.5 | nM | 7.39 |
| CHEMBL290240 | — | Ki | = | 50.4 | nM | 7.30 |
| CHEMBL290463 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL416431 | — | Ki | = | 62.8 | nM | 7.20 |
| CHEMBL41245 | — | Ki | = | 85.5 | nM | 7.07 |
| CHEMBL41245 | — | Ki | = | 85.5 | nM | 7.07 |
| CHEMBL287981 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL418616 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL41883 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL289494 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL289320 | — | Ki | = | 395.0 | nM | 6.40 |
| CHEMBL289137 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL416788 | — | Ki | = | 945.0 | nM | 6.03 |
| CHEMBL41550 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL441427 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL38511 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL40859 | — | Ki | > | 1000.0 | nM | - |