Assay Detail
Functional
CHEMBL756459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against growth of LPS stimulated human peripheral blood mononuclear cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.22 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.40 |
| CHEMBL149807 | — | — | 1 | 5.35 |
| CHEMBL153791 | — | — | 1 | 5.01 |
| CHEMBL153147 | — | — | 1 | 4.92 |
| CHEMBL345503 | — | — | 1 | 4.66 |
| CHEMBL152938 | — | — | 1 | 4.65 |
| CHEMBL153146 | — | — | 1 | 4.56 |
| CHEMBL153144 | — | — | 1 | - |
| CHEMBL149800 | — | — | 1 | - |
| CHEMBL152971 | — | — | 1 | - |
| CHEMBL265800 | — | — | 1 | - |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | - |
| CHEMBL153733 | — | — | 1 | - |
| CHEMBL152929 | — | — | 1 | - |
| CHEMBL153603 | — | — | 1 | - |
| CHEMBL1430 | PENICILLAMINE | 4.0 | 1 | - |
| CHEMBL357569 | — | — | 1 | - |
| CHEMBL358470 | — | — | 1 | - |
| CHEMBL153008 | — | — | 1 | - |
| CHEMBL153233 | — | — | 1 | - |
| CHEMBL150520 | — | — | 1 | - |
| CHEMBL153703 | — | — | 1 | - |
| CHEMBL356646 | — | — | 1 | - |
| CHEMBL434503 | — | — | 1 | - |
| CHEMBL153357 | — | — | 1 | - |
| CHEMBL345534 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL155045 | — | — | 1 | - |
| CHEMBL153314 | — | — | 1 | - |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL149807 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL153791 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL153147 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL345503 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL152938 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL153146 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL153733 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL149693 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL152929 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153603 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1430 | PENICILLAMINE | IC50 | > | 30000.0 | nM | - |
| CHEMBL357569 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL358470 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL149800 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153563 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL155561 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL424337 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153167 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153483 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL149553 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL358920 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL421 | SULFASALAZINE | IC50 | > | 30000.0 | nM | - |
| CHEMBL265800 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL152971 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153144 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153008 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153233 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL150520 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153703 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL356646 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL434503 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153357 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL345534 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | > | 30000.0 | nM | - |
| CHEMBL155045 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL153314 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1366 | AURANOFIN | IC50 | > | 30000.0 | nM | - |