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Assay Detail

CHEMBL756632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against P388 cells is the dose giving 50% decrease in the formation of formazan dye
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Intermediate

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts.
Katada J, Iijima K, Muramatsu M, Takami M, Yasuda E, Hayashi M, Hattori M, Hayashi Y.
Bioorg Med Chem Lett (1999) 9 : 797 -802
PubMed 10206538 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.82 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL350405 1 8.96
CHEMBL167823 1 8.28
CHEMBL167604 1 8.13
CHEMBL436045 1 7.66
CHEMBL166625 1 7.54
CHEMBL165339 1 7.54
CHEMBL167868 1 7.54
CHEMBL166583 1 7.46
CHEMBL166624 1 6.77
CHEMBL166578 1 6.72
CHEMBL355363 1 5.89
CHEMBL353911 1 5.26
CHEMBL167869 1 5.14
CHEMBL167931 1 4.92
CHEMBL353407 1 4.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL350405 IC50 = 1.1 nM 8.96
CHEMBL167823 IC50 = 5.2 nM 8.28
CHEMBL167604 IC50 = 7.4 nM 8.13
CHEMBL436045 IC50 = 22.0 nM 7.66
CHEMBL166625 IC50 = 29.0 nM 7.54
CHEMBL165339 IC50 = 29.0 nM 7.54
CHEMBL167868 IC50 = 29.0 nM 7.54
CHEMBL166583 IC50 = 35.0 nM 7.46
CHEMBL166624 IC50 = 170.0 nM 6.77
CHEMBL166578 IC50 = 190.0 nM 6.72
CHEMBL355363 IC50 = 1300.0 nM 5.89
CHEMBL353911 IC50 = 5500.0 nM 5.26
CHEMBL167869 IC50 = 7300.0 nM 5.14
CHEMBL167931 IC50 = 12000.0 nM 4.92
CHEMBL353407 IC50 = 33000.0 nM 4.48