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Assay Detail

CHEMBL756695

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Functional
Antiproliferative activity measured against P388 Leukemia cells
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Intermediate

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Moreau P, Anizon F, Sancelme M, Prudhomme M, Bailly C, Carrasco C, Ollier M, Sevère D, Riou JF, Fabbro D, Meyer T, Aubertin AM.
J Med Chem (1998) 41 : 1631 -1640
PubMed 9572888 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.91 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3350563 1 6.28
CHEMBL3350558 2 6.21
CHEMBL3350557 1 6.16
CHEMBL3350564 1 6.04
CHEMBL3350560 1 5.97
CHEMBL370100 REBECCAMYCIN 1 5.91
CHEMBL3350561 1 5.47
CHEMBL3350565 1 5.20
CHEMBL3350559 1 -
CHEMBL3350566 1 -
CHEMBL3350562 1 -
CHEMBL3350556 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3350563 IC50 = 520.0 nM 6.28
CHEMBL3350558 IC50 = 610.0 nM 6.21
CHEMBL3350557 IC50 = 690.0 nM 6.16
CHEMBL3350564 IC50 = 910.0 nM 6.04
CHEMBL3350560 IC50 = 1060.0 nM 5.97
CHEMBL370100 REBECCAMYCIN IC50 = 1220.0 nM 5.91
CHEMBL3350561 IC50 = 3390.0 nM 5.47
CHEMBL3350565 IC50 = 6360.0 nM 5.20
CHEMBL3350559 IC50 > 19000.0 nM -
CHEMBL3350558 IC50 > 16700.0 nM -
CHEMBL3350566 IC50 > 19000.0 nM -
CHEMBL3350562 IC50 > 19000.0 nM -
CHEMBL3350556 IC50 > 125000.0 nM -