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Assay Detail

CHEMBL756785

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Functional
In vitro anticancer activity against murine leukemic P388 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Expert

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents.
Li WT, Hwang DR, Chen CP, Shen CW, Huang CL, Chen TW, Lin CH, Chang YL, Chang YY, Lo YK, Tseng HY, Lin CC, Song JS, Chen HC, Chen SJ, Wu SH, Chen CT.
J Med Chem (2003) 46 : 1706 -1715
PubMed 12699388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.68 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL46222 1 8.52
CHEMBL46330 1 8.30
CHEMBL48087 1 8.30
CHEMBL50280 1 8.30
CHEMBL295063 1 8.22
CHEMBL297119 1 8.15
CHEMBL295137 1 8.05
CHEMBL412438 1 8.00
CHEMBL45601 1 7.92
CHEMBL301318 1 7.75
CHEMBL46211 1 7.27
CHEMBL44742 1 7.21
CHEMBL49642 INDIBULIN 2.0 1 7.11
CHEMBL296654 1 6.95
CHEMBL48116 1 6.78
CHEMBL295694 1 6.12
CHEMBL297334 1 -
CHEMBL295874 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL46222 IC50 = 3.0 nM 8.52
CHEMBL46330 IC50 = 5.0 nM 8.30
CHEMBL48087 IC50 = 5.0 nM 8.30
CHEMBL50280 IC50 = 5.0 nM 8.30
CHEMBL295063 IC50 = 6.0 nM 8.22
CHEMBL297119 IC50 = 7.0 nM 8.15
CHEMBL295137 IC50 = 9.0 nM 8.05
CHEMBL412438 IC50 = 10.0 nM 8.00
CHEMBL45601 IC50 = 12.0 nM 7.92
CHEMBL301318 IC50 = 18.0 nM 7.75
CHEMBL46211 IC50 = 54.0 nM 7.27
CHEMBL44742 IC50 = 62.0 nM 7.21
CHEMBL49642 INDIBULIN IC50 = 77.0 nM 7.11
CHEMBL296654 IC50 = 112.0 nM 6.95
CHEMBL48116 IC50 = 167.0 nM 6.78
CHEMBL295694 IC50 = 756.0 nM 6.12
CHEMBL297334 IC50 > 1000.0 nM -
CHEMBL295874 IC50 > 1000.0 nM -