Assay Detail
Functional
CHEMBL756786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNA synthesis was measured as the concentration required to cause 50% reduction (in 1h) in methyl [3H]thymidine incorporation into acid precipitable material using P388 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
"Reverse" and "symmetrical" analogues of actinomycin D: metabolic activation and in vitro and in vivo tumor growth inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.65 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439714 | — | — | 1 | 9.10 |
| CHEMBL406071 | — | — | 1 | 8.96 |
| CHEMBL385161 | — | — | 1 | 8.29 |
| CHEMBL267466 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439714 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL406071 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL385161 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL267466 | — | IC50 | = | 5.7 | nM | 8.24 |