Assay Detail
Functional
CHEMBL756787
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Inhibition of RNA synthesis was measured as the concentration required to cause 50% reduction (in 1h) in 2-[14C]uridine incorporation into acid precipitable material using P388 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
"Reverse" and "symmetrical" analogues of actinomycin D: metabolic activation and in vitro and in vivo tumor growth inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.97 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439714 | — | — | 1 | 10.15 |
| CHEMBL406071 | — | — | 1 | 8.94 |
| CHEMBL267466 | — | — | 1 | 8.49 |
| CHEMBL385161 | — | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439714 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL406071 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL267466 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL385161 | — | IC50 | = | 5.1 | nM | 8.29 |