Assay Detail
Functional
CHEMBL756788
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Inhibitory activity against murine P388 leukemia (P388) cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.36 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162885 | — | — | 1 | 8.25 |
| CHEMBL433703 | — | — | 1 | 8.17 |
| CHEMBL162739 | — | — | 1 | 8.08 |
| CHEMBL162451 | — | — | 1 | 8.03 |
| CHEMBL162781 | — | — | 1 | 8.00 |
| CHEMBL349474 | — | — | 1 | 7.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.82 |
| CHEMBL163525 | — | — | 1 | 7.80 |
| CHEMBL350147 | — | — | 1 | 7.51 |
| CHEMBL162112 | — | — | 1 | 7.43 |
| CHEMBL355827 | — | — | 1 | 7.38 |
| CHEMBL163577 | — | — | 1 | 7.07 |
| CHEMBL353127 | — | — | 1 | 7.01 |
| CHEMBL351239 | — | — | 1 | 6.66 |
| CHEMBL351244 | — | — | 1 | 6.52 |
| CHEMBL164407 | — | — | 1 | 5.96 |
| CHEMBL163314 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162885 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL433703 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL162739 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL162451 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL162781 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL349474 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL163525 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL350147 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL162112 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL355827 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL163577 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL353127 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL351239 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL351244 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL164407 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL163314 | — | IC50 | = | 2700.0 | nM | 5.57 |