Assay Detail
Binding
CHEMBL757059
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Binding affinity against mu opiate receptor
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.55 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115222 | — | — | 1 | 9.05 |
| CHEMBL114379 | — | — | 1 | 8.92 |
| CHEMBL324297 | — | — | 1 | 8.82 |
| CHEMBL115652 | — | — | 1 | 8.70 |
| CHEMBL420863 | — | — | 1 | 8.62 |
| CHEMBL325945 | — | — | 1 | 8.20 |
| CHEMBL114484 | — | — | 1 | 7.80 |
| CHEMBL326962 | — | — | 1 | 7.78 |
| CHEMBL115229 | — | — | 1 | 7.71 |
| CHEMBL325750 | — | — | 1 | 7.53 |
| CHEMBL115280 | — | — | 1 | 7.08 |
| CHEMBL115444 | — | — | 1 | 6.83 |
| CHEMBL114825 | — | — | 1 | 6.75 |
| CHEMBL115709 | — | — | 1 | 6.71 |
| CHEMBL114280 | — | — | 1 | 6.63 |
| CHEMBL111918 | — | — | 1 | 6.13 |
| CHEMBL325258 | — | — | 1 | 6.10 |
| CHEMBL332697 | — | — | 1 | 6.02 |
| CHEMBL115549 | — | — | 1 | 5.98 |
| CHEMBL326320 | — | — | 1 | 5.91 |
| CHEMBL326263 | — | — | 1 | 5.83 |
| CHEMBL325674 | — | — | 1 | 5.83 |
| CHEMBL115249 | — | — | 1 | 5.77 |
| CHEMBL115076 | — | — | 1 | 5.76 |
| CHEMBL420500 | — | — | 1 | 5.64 |
| CHEMBL325697 | — | — | 1 | 5.64 |
| CHEMBL333843 | — | — | 1 | 5.61 |
| CHEMBL114299 | — | — | 1 | 5.59 |
| CHEMBL419214 | — | — | 1 | 5.54 |
| CHEMBL116735 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115222 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL114379 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL324297 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL115652 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL420863 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL325945 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL114484 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL326962 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL115229 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL325750 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL115280 | — | IC50 | = | 83.5 | nM | 7.08 |
| CHEMBL115444 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL114825 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL115709 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL114280 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL111918 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL325258 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL332697 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL115549 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL326320 | — | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL326263 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL325674 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL115249 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL115076 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL420500 | — | IC50 | = | 2285.0 | nM | 5.64 |
| CHEMBL325697 | — | IC50 | = | 2285.0 | nM | 5.64 |
| CHEMBL333843 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL114299 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL419214 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL116735 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL117537 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL420499 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL325516 | — | IC50 | = | 4015.0 | nM | 5.40 |
| CHEMBL113956 | — | IC50 | = | 4545.0 | nM | 5.34 |
| CHEMBL324479 | — | IC50 | = | 4955.0 | nM | 5.30 |
| CHEMBL116463 | — | IC50 | = | 6545.0 | nM | 5.18 |