Assay Detail
Functional
CHEMBL757210
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In vitro anti-HIV activity was determined in peripheral blood mononuclear cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.07 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591804 | NAVURIDINE | 2.0 | 1 | 6.70 |
| CHEMBL3350999 | — | — | 1 | 5.80 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 5.70 |
| CHEMBL3350580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591804 | NAVURIDINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3350999 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3350580 | — | EC50 | = | 1.0 | ug hr ml-1 | - |