Assay Detail
Binding
CHEMBL757311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from Opioid receptor mu 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.08 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.57 |
| CHEMBL316930 | — | — | 1 | 6.85 |
| CHEMBL329719 | — | — | 1 | 5.89 |
| CHEMBL98324 | — | — | 1 | 5.70 |
| CHEMBL319592 | — | — | 1 | 5.35 |
| CHEMBL95319 | — | — | 1 | 5.10 |
| CHEMBL95847 | — | — | 1 | - |
| CHEMBL319589 | — | — | 1 | - |
| CHEMBL441270 | — | — | 1 | - |
| CHEMBL318957 | — | — | 1 | - |
| CHEMBL95408 | — | — | 1 | - |
| CHEMBL317536 | — | — | 1 | - |
| CHEMBL329473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL316930 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL329719 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL98324 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL319592 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL95319 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL95847 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL319589 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL441270 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL318957 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL95408 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL317536 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL329473 | — | Ki | > | 6000.0 | nM | - |