Assay Detail
Binding
CHEMBL757315
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Binding affinity to delta opioid receptor was measured using [3H]DADLE
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.64 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.39 |
| CHEMBL346165 | — | — | 1 | 9.19 |
| CHEMBL346173 | — | — | 1 | 9.11 |
| CHEMBL356861 | — | — | 1 | 8.92 |
| CHEMBL149256 | — | — | 1 | 8.89 |
| CHEMBL146907 | — | — | 1 | 8.74 |
| CHEMBL357680 | — | — | 1 | 8.38 |
| CHEMBL150028 | — | — | 1 | 8.35 |
| CHEMBL358208 | — | — | 1 | 8.26 |
| CHEMBL356387 | — | — | 1 | 8.10 |
| CHEMBL348011 | — | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL346165 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL346173 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL356861 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL149256 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL146907 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL357680 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL150028 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL358208 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL356387 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL348011 | — | Ki | = | 18.7 | nM | 7.73 |