Assay Detail
Functional
CHEMBL757673
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Concentration required for 50% inhibition of P388 murine leukemia cell growth in MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.59 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36455 | E-COMBRETASTATIN A-4 | — | 1 | 8.59 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 8.00 |
| CHEMBL151766 | — | — | 1 | 7.48 |
| CHEMBL10557 | — | — | 1 | 6.96 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.80 |
| CHEMBL36556 | — | — | 1 | 5.70 |
| CHEMBL289686 | — | — | 1 | 4.72 |
| CHEMBL150137 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36455 | E-COMBRETASTATIN A-4 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL151766 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL10557 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL36556 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL289686 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL150137 | — | IC50 | = | 33000.0 | nM | 4.48 |