Assay Detail
Functional
CHEMBL757824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against opioid receptor mu1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.57 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322515 | — | — | 1 | 9.00 |
| CHEMBL325536 | — | — | 1 | 8.40 |
| CHEMBL111230 | — | — | 1 | 8.10 |
| CHEMBL112974 | — | — | 1 | 7.72 |
| CHEMBL111347 | — | — | 1 | 7.68 |
| CHEMBL111192 | — | — | 1 | 7.44 |
| CHEMBL109563 | — | — | 1 | 7.34 |
| CHEMBL113684 | — | — | 1 | 6.95 |
| CHEMBL109598 | — | — | 1 | 6.91 |
| CHEMBL320991 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322515 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL325536 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL111230 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL112974 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL111347 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL111192 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL109563 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL113684 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL109598 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL320991 | — | Ki | = | 626.0 | nM | 6.20 |