Assay Detail

CHEMBL758428

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Functional

Cytotoxicity of compound was tested against P-388 cell line (mouse leukemia) after incubation for 24 hour

ChEMBL ↗

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Target

P388 (CHEMBL389) ↗

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Primary target P388

CHEMBL389

Anchored from Assay target.

Protein identity P388

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	P388
Confidence	1 — Organism
Curated By	Intermediate

Target

P388 (CHEMBL389) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

A new designed tumor selective daunomycin derivative

Maligres P, Nicolaou K, Wrasidlo W
Bioorg Med Chem Lett (1993) 3 : 1051 -1054
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.26	6.41

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1563	DAUNORUBICIN HYDROCHLORIDE	4.0	1	6.41
CHEMBL274803	—	—	1	6.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1563	DAUNORUBICIN HYDROCHLORIDE	IC50	=	390.0	nM	6.41
CHEMBL274803	—	IC50	=	780.0	nM	6.11