Assay Detail
Functional
CHEMBL758604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for its cytotoxic potency against P388 cell line
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.51 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.50 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | — | 1 | 7.80 |
| CHEMBL84903 | — | — | 1 | 7.40 |
| CHEMBL78126 | — | — | 1 | 6.50 |
| CHEMBL82612 | — | — | 1 | 6.40 |
| CHEMBL77720 | — | — | 1 | 5.90 |
| CHEMBL316045 | — | — | 1 | 5.40 |
| CHEMBL414884 | — | — | 1 | 5.40 |
| CHEMBL86108 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL84903 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL78126 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL82612 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL77720 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL316045 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL414884 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL86108 | — | IC50 | = | 5011.87 | nM | 5.30 |