Assay Detail
Functional
CHEMBL758667
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In vitro cytotoxicity measured by quantifying clonogenic survival in soft agar following a 1-hour transient exposure of p388 mouse leukemia cells.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.80 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30104 | — | — | 1 | 8.36 |
| CHEMBL27233 | — | — | 1 | 7.96 |
| CHEMBL121442 | — | — | 1 | 7.66 |
| CHEMBL122716 | — | — | 1 | 7.62 |
| CHEMBL121666 | — | — | 1 | 7.60 |
| CHEMBL25908 | — | — | 1 | 6.82 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.82 |
| CHEMBL283395 | — | — | 1 | 6.52 |
| CHEMBL287205 | — | — | 1 | 6.48 |
| CHEMBL27542 | — | — | 1 | 6.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.08 |
| CHEMBL121192 | — | — | 1 | 6.07 |
| CHEMBL281022 | — | — | 1 | 5.24 |
| CHEMBL330996 | — | — | 1 | 5.02 |
| CHEMBL333026 | — | — | 1 | 4.96 |
| CHEMBL120915 | — | — | 1 | 4.92 |
| CHEMBL27064 | — | — | 1 | 4.89 |
| CHEMBL30099 | — | — | 1 | 4.80 |
| CHEMBL332805 | — | — | 1 | 4.68 |
| CHEMBL22077 | HYCANTHONE | 2.0 | 1 | 4.55 |
| CHEMBL30053 | — | — | 1 | 4.52 |
| CHEMBL29836 | — | — | 1 | 4.35 |
| CHEMBL333641 | — | — | 1 | 4.31 |
| CHEMBL280609 | — | — | 1 | 4.26 |
| CHEMBL121547 | — | — | 1 | 4.09 |
| CHEMBL434812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30104 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL27233 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL121442 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL122716 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL121666 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL25908 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL43 | AMSACRINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL283395 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL287205 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL27542 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL121192 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL281022 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL330996 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL333026 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL120915 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL27064 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL30099 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL332805 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL22077 | HYCANTHONE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL30053 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL29836 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL333641 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL280609 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL121547 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL434812 | — | IC50 | = | 106000.0 | nM | - |