Assay Detail
Binding
CHEMBL758847
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Compound was evaluated for opioid receptor affinity against the receptor site model site 5
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.97 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80 | NALOXONE | 4.0 | 1 | 6.81 |
| CHEMBL1500 | DIHYDROMORPHINE | — | 1 | 6.70 |
| CHEMBL149414 | — | — | 1 | 5.38 |
| CHEMBL340032 | DADLE | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80 | NALOXONE | Kd | = | 154.0 | nM | 6.81 |
| CHEMBL1500 | DIHYDROMORPHINE | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL149414 | — | Kd | = | 4160.0 | nM | 5.38 |
| CHEMBL340032 | DADLE | Kd | = | 10000.0 | nM | 5.00 |