Assay Detail
Functional
CHEMBL759008
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Compound was evaluated for cytotoxicity against P388 leukemia cell line.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Drug delivery systems employing 1,4- or 1,6-elimination: poly(ethylene glycol) prodrugs of amine-containing compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.21 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 8.52 |
| CHEMBL331086 | — | — | 1 | 8.10 |
| CHEMBL123331 | — | — | 1 | 7.82 |
| CHEMBL330870 | — | — | 1 | 7.75 |
| CHEMBL120954 | — | — | 1 | 7.57 |
| CHEMBL332860 | — | — | 1 | 7.46 |
| CHEMBL331074 | — | — | 1 | 7.26 |
| CHEMBL434218 | — | — | 1 | 6.89 |
| CHEMBL3142969 | — | — | 1 | 6.80 |
| CHEMBL333365 | — | — | 1 | 6.75 |
| CHEMBL332986 | — | — | 1 | 6.38 |
| CHEMBL332068 | — | — | 1 | 6.34 |
| CHEMBL332307 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL331086 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL123331 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL330870 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL120954 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL332860 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL331074 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL434218 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3142969 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL333365 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL332986 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL332068 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL332307 | — | IC50 | = | 825.0 | nM | 6.08 |