Assay Detail
Functional
CHEMBL760109
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Effective concentration for antagonistic activity towards human progesterone in CV-1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.98 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65743 | — | — | 1 | 7.87 |
| CHEMBL418684 | — | — | 1 | 7.59 |
| CHEMBL303293 | — | — | 1 | 6.71 |
| CHEMBL66198 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65743 | — | EC50 | = | 13.5 | nM | 7.87 |
| CHEMBL418684 | — | EC50 | = | 25.4 | nM | 7.59 |
| CHEMBL303293 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL66198 | — | EC50 | = | 1871.0 | nM | 5.73 |