Assay Detail
Binding
CHEMBL760114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.89 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302321 | — | — | 1 | 8.15 |
| CHEMBL307113 | — | — | 1 | 7.92 |
| CHEMBL306450 | — | — | 1 | 7.48 |
| CHEMBL71834 | — | — | 1 | 7.25 |
| CHEMBL70943 | — | — | 1 | 6.22 |
| CHEMBL71137 | — | — | 1 | 6.13 |
| CHEMBL70749 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302321 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL307113 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL306450 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL71834 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL70943 | — | Ki | = | 601.0 | nM | 6.22 |
| CHEMBL71137 | — | Ki | = | 733.0 | nM | 6.13 |
| CHEMBL70749 | — | Ki | = | 8600.0 | nM | 5.07 |