Assay Detail
Binding
CHEMBL760197
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Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.06 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107881 | — | — | 1 | 7.82 |
| CHEMBL100004 | — | — | 1 | 7.16 |
| CHEMBL321486 | — | — | 1 | 6.30 |
| CHEMBL108238 | — | — | 1 | 6.22 |
| CHEMBL108291 | — | — | 1 | 6.04 |
| CHEMBL108714 | — | — | 1 | 6.00 |
| CHEMBL108295 | — | — | 1 | 6.00 |
| CHEMBL108086 | — | — | 1 | 5.98 |
| CHEMBL326215 | — | — | 1 | 5.68 |
| CHEMBL109083 | — | — | 1 | 5.36 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107881 | — | Ki | = | 15.09 | nM | 7.82 |
| CHEMBL100004 | — | Ki | = | 68.77 | nM | 7.16 |
| CHEMBL321486 | — | Ki | = | 505.1 | nM | 6.30 |
| CHEMBL108238 | — | Ki | = | 603.2 | nM | 6.22 |
| CHEMBL108291 | — | Ki | = | 912.7 | nM | 6.04 |
| CHEMBL108714 | — | Ki | = | 1001.0 | nM | 6.00 |
| CHEMBL108295 | — | Ki | = | 1012.0 | nM | 6.00 |
| CHEMBL108086 | — | Ki | = | 1045.0 | nM | 5.98 |
| CHEMBL326215 | — | Ki | = | 2092.0 | nM | 5.68 |
| CHEMBL109083 | — | Ki | = | 4408.0 | nM | 5.36 |
| CHEMBL475534 | NITRENDIPINE | Ki | = | 73310.0 | nM | 4.13 |