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Assay Detail

CHEMBL760411

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against P388 leukemia cell line
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Expert

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain.
Valu KK, Gourdie TA, Boritzki TJ, Gravatt GL, Baguley BC, Wilson WR, Wakelin LP, Woodgate PD, Denny WA.
J Med Chem (1990) 33 : 3014 -3019
PubMed 2231599 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.37 7.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3216384 1 7.33
CHEMBL17138 1 7.30
CHEMBL3215549 1 7.21
CHEMBL323110 1 7.20
CHEMBL538019 1 7.14
CHEMBL3216399 1 7.09
CHEMBL3215994 1 7.07
CHEMBL264736 1 6.87
CHEMBL3216396 1 6.44
CHEMBL3215532 1 6.43
CHEMBL275431 1 6.42
CHEMBL278918 1 6.39
CHEMBL545030 1 6.31
CHEMBL17360 1 6.20
CHEMBL277152 1 6.12
CHEMBL273595 1 5.86
CHEMBL555534 1 5.72
CHEMBL544328 1 5.64
CHEMBL543624 1 5.58
CHEMBL515 CHLORAMBUCIL 4.0 1 5.12
CHEMBL274253 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3216384 IC50 = 47.0 nM 7.33
CHEMBL17138 IC50 = 50.0 nM 7.30
CHEMBL3215549 IC50 = 61.0 nM 7.21
CHEMBL323110 IC50 = 63.0 nM 7.20
CHEMBL538019 IC50 = 72.0 nM 7.14
CHEMBL3216399 IC50 = 82.0 nM 7.09
CHEMBL3215994 IC50 = 86.0 nM 7.07
CHEMBL264736 IC50 = 136.0 nM 6.87
CHEMBL3216396 IC50 = 360.0 nM 6.44
CHEMBL3215532 IC50 = 372.0 nM 6.43
CHEMBL275431 IC50 = 380.0 nM 6.42
CHEMBL278918 IC50 = 410.0 nM 6.39
CHEMBL545030 IC50 = 490.0 nM 6.31
CHEMBL17360 IC50 = 630.0 nM 6.20
CHEMBL277152 IC50 = 750.0 nM 6.12
CHEMBL273595 IC50 = 1380.0 nM 5.86
CHEMBL555534 IC50 = 1900.0 nM 5.72
CHEMBL544328 IC50 = 2300.0 nM 5.64
CHEMBL543624 IC50 = 2600.0 nM 5.58
CHEMBL515 CHLORAMBUCIL IC50 = 7500.0 nM 5.12
CHEMBL274253 IC50 = 39000.0 nM 4.41