Assay Detail
Functional
CHEMBL760442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAF-induced platelet aggregation
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.36 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102070 | — | — | 1 | 8.05 |
| CHEMBL100497 | — | — | 1 | 8.04 |
| CHEMBL322184 | — | — | 1 | 8.04 |
| CHEMBL102918 | — | — | 1 | 8.04 |
| CHEMBL103596 | — | — | 1 | 7.96 |
| CHEMBL103393 | — | — | 1 | 7.92 |
| CHEMBL103476 | — | — | 1 | 7.89 |
| CHEMBL318563 | — | — | 1 | 7.85 |
| CHEMBL420092 | — | — | 1 | 7.80 |
| CHEMBL100641 | — | — | 1 | 7.77 |
| CHEMBL100642 | — | — | 1 | 7.75 |
| CHEMBL103995 | — | — | 1 | 7.75 |
| CHEMBL100809 | — | — | 1 | 7.70 |
| CHEMBL100340 | — | — | 1 | 7.70 |
| CHEMBL319229 | — | — | 1 | 7.70 |
| CHEMBL101245 | — | — | 1 | 7.70 |
| CHEMBL431049 | — | — | 1 | 7.66 |
| CHEMBL103903 | — | — | 1 | 7.58 |
| CHEMBL103560 | — | — | 1 | 7.58 |
| CHEMBL100547 | — | — | 1 | 7.55 |
| CHEMBL103408 | — | — | 1 | 7.52 |
| CHEMBL103571 | — | — | 1 | 7.52 |
| CHEMBL100190 | — | — | 1 | 7.52 |
| CHEMBL102774 | — | — | 1 | 7.51 |
| CHEMBL99795 | — | — | 1 | 7.47 |
| CHEMBL103368 | — | — | 1 | 7.44 |
| CHEMBL103773 | — | — | 1 | 7.42 |
| CHEMBL100493 | — | — | 1 | 7.40 |
| CHEMBL418792 | — | — | 1 | 7.39 |
| CHEMBL103761 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102070 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL100497 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL102918 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL322184 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL103596 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL103393 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL103476 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL318563 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL420092 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL100641 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL100642 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL103995 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL100340 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL100809 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL319229 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL101245 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL431049 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL103903 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL103560 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL100547 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL103408 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL103571 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL100190 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL102774 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL99795 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL103368 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL103773 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL100493 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL418792 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL103761 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL103180 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL273945 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL103801 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL102666 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL318163 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL100971 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL103171 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL319960 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL318159 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL103477 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL103561 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL280164 | APAFANT | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL100597 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL318460 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL320676 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL421204 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL100853 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL101957 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL103546 | — | IC50 | = | 15200.0 | nM | 4.82 |